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A CD19-specific CAR T-cell therapy with intermediate affinity for CD19 produced a response in 77% of adults with refractory disease. Overall survival was 61% at 12 months, and serious toxic effects were rare.
Original ArticleDec 09, 2024Five patients with hemophilia A had dramatic reductions in bleeding episodes after undergoing autologous HSCT with lentiviral vector–transduced cells encoding a CD68-targeted factor VIII transgene.
Original ArticleVOL. 391 NO. 23Dec 12, 2024CMEIn a trial of percutaneous coronary intervention or conservative treatment in patients undergoing TAVI, PCI was associated with a lower risk of a composite of death, MI, or urgent revascularization at a median of 2 years.
Original ArticleDec 07, 2024The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or high risk of relapse significantly improved disease-free survival.
Original ArticleVOL. 391 NO. 23Dec 12, 2024In this open-label, proof-of-concept study in Brazil, bedaquiline showed substantial antimicrobial activity against Mycobacterium leprae in nine patients.
Original ArticleVOL. 391 NO. 23Dec 12, 2024A phase 1 trial of nexiguran ziclumeran (nex-z) to treat transthyretin cardiomyopathy showed a rapid and durable reduction of 90% in serum transthyretin levels and evidence of disease stabilization.
Original ArticleDec 12, 2024This randomized trial involving patients with clinically node-negative, T1 breast cancer showed that the omission of axillary surgery was noninferior to sentinel-lymph-node biopsy.
Original ArticleDec 09, 2024In a trial involving patients with subarachnoid hemorrhage and anemia, liberal transfusion of red cells did not result in a lower risk of an unfavorable neurologic outcome than a more restrictive strategy.
Original ArticleVOL. 391 NO. 23Dec 12, 2024In a phase 3 trial, adults with type 2 diabetes who had not previously received insulin were assigned to receive once-weekly efsitora or once-daily degludec. Efsitora was noninferior to degludec in reducing glycated hemoglobin levels.
Original ArticleDec 11, 2024The selective estrogen-receptor degrader imlunestrant plus abemaciclib led to a median progression-free survival of 9.4 months among patients with ER-positive, HER2-negative breast cancer (vs. 5.5 months with imlunestrant alone).
Original ArticleDec 09, 2024Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring.
Original ArticleVOL. 391 NO. 22Dec 05, 2024In a phase 2 trial involving participants taking a nucleoside or nucleotide analogue, 23% of those assigned to receive xalnesiran plus pegylated interferon alfa-2a had HBsAg loss at 24 weeks after the end of treatment.
Original ArticleVOL. 391 NO. 22Dec 05, 2024Among patients with metastatic breast cancer with low HER2 expression, treatment with trastuzumab deruxtecan prolonged progression-free survival as compared with the physician’s choice of chemotherapy.
Original ArticleVOL. 391 NO. 22Dec 05, 2024Of 107 participants with unusual or nonreportable results from prenatal cell-free DNA sequencing performed by commercial laboratories in North America, approximately half had an occult cancer.
Original ArticleVOL. 391 NO. 22Dec 05, 2024Measurement of low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and lipoprotein(a) predicted the 30-year cardiovascular disease risk among women enrolled in the Women’s Health Study.
Original ArticleVOL. 391 NO. 22Dec 05, 2024CMEIn this multicenter, randomized trial, edoxaban monotherapy led to a lower risk of net clinical adverse events at 12 months than dual antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease.
Original ArticleNov 27, 2024In this phase 3 trial, the incidence of HIV infection with twice-yearly lenacapavir was lower than both the background incidence and the incidence with emtricitabine–tenofovir disoproxil fumarate.
Original ArticleVOL. 391 NO. 21Nov 28, 2024Pneumococcal conjugate vaccines are an important but costly part of childhood vaccination. This trial assessed immunogenicity of fractional-dose regimens — a key consideration as countries transition out of Gavi support.
Original ArticleVOL. 391 NO. 21Nov 28, 2024CMEThe combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy.
Original ArticleVOL. 391 NO. 21Nov 28, 2024In this cluster-randomized trial in Vietnam, a two-dose PCV10 vaccination schedule was not inferior to the routine three-dose schedule in preventing vaccine serotype carriage in infants and toddlers.
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December 16, 2024
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Primary Care
Needham, Massachusetts
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Albany, Oregon
Family Medicine
Stamford, Connecticut
Internal Medicine
Pocatello, Idaho
Pulmonary Disease
Asheville, North Carolina
Internal Medicine
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