袁彩

近五年代表性论文：（*为通讯作者）

(1) Xu, Y.; Hu, Y.; Wu, G.; Niu, L.; Fang, C.; Li, Y.; Jiang, L.; Yuan, C.*; Huang, M.* Specific inhibition on PAI-1 reduces the dose of Alteplase for ischemic stroke treatment. International Journal of Biological Macromolecules 2024, 257.

(2) Wang, G.; Li, J.; Zhang, W.; Jiang, L.; Mai, Y.; Chen, J.; Deng, L.; Chen, L.; Lin, Y.; Li, X.; Zou, H.; Xu, P.; Jiang, L.; Yuan, C.*; Huang, M.* A class of photosensitizer highly effective to control bacterial infection in plants even on rainy days with dim light. Dyes and Pigments 2024, 112065.

(3) Xu, Y.; Chen, D.; Liu, P.; Hu, Y.; Peng, S.; Chen, S.; Li, Y.; Lin, W.; Jiang, L.; Yuan, C.*; Huang, M.* A triple fusion tissue-type plasminogen activator (TriF-ΔtPA) enhanced thrombolysis in carotid embolism-induced stroke model. International Journal of Pharmaceutics 2023, 637, 122878.

(4) Liu, D.; Jiang, L.; Chen, J.; Chen, Z.; Yuan, C.*; Lin, D. *; Huang, M.* Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy. Molecules 2023, 28 (12).

(5) Liao, X.; Ji, P.; Chi, K.; Chen, X.; Zhou, Y.; Chen, S.; Cheng, Y.; Flaumenhaft, R.; Yuan, C.*; Huang, M.* Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Advances 2023, 13 (17), 11464-11471.

(6) Li, H.; Wang, Z.; Yu, S.; Chen, S.; Zhou, Y.; Qu, Y.; Xu, P.; Jiang, L.; Yuan, C.*; Huang, M.* Albumin-based drug carrier targeting urokinase receptor for cancer therapy. International Journal of Pharmaceutics 2023, 634, 122636.

(7) Yu, S.; Sui, Y.; Wang, J.; Li, Y.; Li, H.; Cao, Y.; Chen, L.; Jiang, L.; Yuan, C.*; Huang, M.* Crystal structure and cellular functions of uPAR dimer. Nature Communications 2022, 13 (1), 1665.

(8) Wang, G.; Yang, L.; Jiang, L.; Chen, J.; Jing, Q.; Mai, Y.; Deng, L.; Lin, Y.; Chen, L.; Chen, Z.; Xu, P.; Jiang, L.; Yuan, C.*; Huang, M.* A new class of quaternary ammonium compounds as potent and environmental friendly disinfectants. Journal of Cleaner Production 2022, 379, 134632.

(9) Liao, X.; Zhuang, X.; Liang, C.; Li, J.; Flaumenhaft, R.; Yuan, C.*; Huang, M.* Flavonoids as Protein Disulfide Isomerase Inhibitors: Key Molecular and Structural Features for the Interaction. Journal of Agricultural and Food Chemistry 2022, 70 (14), 4475-4483.

(10) Liang, C.; Flaumenhaft, R.; Yuan, C.*; Huang, M.* Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug Discovery Today 2022, 27 (2), 626-635.

(11) Liang, C.; Cai, M.; Xu, Y.; Fu, W.; Wu, J.; Liu, Y.; Liao, X.; Ning, J.; Li, J.; Huang, M.*; Yuan, C.* Identification of Antithrombotic Natural Products Targeting the Major Substrate Binding Pocket of Protein Disulfide Isomerase. Journal of Natural Products 2022, 85 (5), 1332-1339.

(12) Huang, Z.; Lin, H.; Yu, S.; Li, H.; Zhou, Y.; Cheng, Y.; Chen, S.; Yuan, C.*; Huang, M.* A versatile insertion point on albumin to accommodate peptides and maintain their activities. International Journal of Biological Macromolecules 2022, 205, 49-54.

(13) Chen, S.#; Yuan, C.#; Jiang, L.; Luo, Z.*; Huang, M.* Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid. International Journal of Biological Macromolecules 2022, 216, 172-178.

(14) Chen, D.; Liu, Y.; Liu, P.; Zhou, Y.; Jiang, L.; Yuan, C.*; Huang, M.* Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition. Drug Delivery 2022, 29 (1), 1824-1835.

(15) Zhang, D.; Chen, J.; Jing, Q.; Chen, Z.; Ullah, A.; Jiang, L.; Zheng, K.; Yuan, C.*; Huang, M.* Development of a Potent Antimicrobial Peptide With Photodynamic Activity. Frontiers in Microbiology 2021, 12, 624465.

(16) Yuan, C.; Guo, Z.; Yu, S.; Jiang, L. *; Huang, M.* Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners. Drug Discovery Today 2021, 26 (4), 1076-1085.

(17) Yu, S.; Sun, G.; Sui, Y.; Li, H.; Mai, Y.; Wang, G.; Zhang, N.; Bi, Y.; Gao, G. F.; Xu, P.; Jiang, L.; Yuan, C.*; Yang, Y.*; Huang, M.* Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds. Dyes and Pigments 2021, 194, 109570.

(18) Liang, C.; Flaumenhaft, R.; Yuan, C.*; Huang, M.* Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug discovery today 2021.

(19) Li, L.; Huang, M.*; Shen, J.; Wang, Y.; Wang, R.; Yuan, C.*; Jiang, L.; Huang, M. Serum Levels of Soluble Platelet Endothelial Cell Adhesion Molecule 1 in COVID-19 Patients Are Associated With Disease Severity. The Journal of Infectious Diseases 2021, 223 (1), 178-179.

(20) Jiang, L.; Yuan, C.*; Huang, M.* A general strategy to inhibit serine protease by targeting its autolysis loop. The FASEB Journal 2021, 35 (2), e21259.

(21) Jiang, L.; Jiang, Y.; Li, L.; Zheng, K.; Yu, S.; Li, J.; Yuan, C.*; Huang, M.* A supramolecular nanocarrier for efficient cancer imaging and therapy by targeting at matriptase. Journal of Controlled Release 2021, 334, 153-163.

(22) Chen, S.; Chen, D.; Liu, Y.; Xu, Y.; Lin, H.; Cheng, Y.; Li, J.; Meng, C.; Liang, M.; Yuan, C.*; Huang, M.* Enhanced clot lysis by a single point mutation in a reteplase variant. British Journal of Haematology 2021, 196 (4), 1076-1085.

(23) Li, L.; Chen, D.; Zheng, K.; Jiang, L.; Dai, T.; Yang, L.; Jiang, L.; Chen, Z.; Yuan, C.*; Huang, M.* Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. ACS Applied Materials & Interfaces 2020, 12 (4), 4221-4230.

(24) Jiang, Y.; Lin, L.; Chen, S.; Jiang, L.; Kriegbaum, M. C.; Grdsvoll, H.; Hansen, L. V.; Li, J.; Ploug, M.; Yuan, C.*; Huang, M.* Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/alpha-neurotoxin Domain. International Journal of Biological Sciences 2020, 16 (6), 981-993.

(25) Jiang, L.; Liu, Y.; Xu, X.; Su, D.; Zou, H.; Liu, J.; Yuan, C.*; Huang, M.* Inhibition of the Citrus Canker Pathogen Using a Photosensitizer Assisted by Sunlight Irradiation. Frontiers in Microbiology 2020, 11, 571691.

(26) 许燕艳; 陈珊莉; 陈丹; 彭双周; 程媛; 李金宇; 李永坤; 江龙光; 袁彩*; 黄明东*. 缺血性脑卒中溶栓药物研究进展. 生物工程学报 2020, 36 (10), 2029-2039.

(27) 梁程辉; 陈丹; 廖馨源; 江龙光; 袁彩*; 黄明东*. 蛋白质二硫键异构酶的结构及抑制剂研究进展. 生物化学与生物物理进展 2020, 47 (07), 595-606.

(28) Shang, L.; Xue, G.; Gong, L.; Zhang, Y.; Peng, S.; Yuan, C.*; Huang, M.* A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent. Analytica Chimica Acta 2019, 1053, 98-104.

(29) Liu, M.; Lin, L.*; Hoyer-Hansen, G.; Ploug, M.; Li, H.; Jiang, L.; Yuan, C.*; Li, J.; Huang, M.* Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Febs Letters 2019, 593 (11), 1236-1247.

(30) Li, R.; Liang, C.; Jiang, L.; Yuan, C.*; Huang, M.* Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochemical and Biophysical Research Communications 2019, 510 (4), 539-544.

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